CAS號(hào) 59669-26-0
英文名 Thiodicarb
通用名 硫雙威
分子式
C10H18N4O4S3
分子量 354.47
結(jié)構(gòu)式 硫雙威
理化性質(zhì) 熔點(diǎn)： 168-172°C
劑型 95%TC 80%WDG。
毒性 大鼠急性經(jīng)口LD50 66mg (水中)/kg、120 mg (玉米油中) /kg，狗>800 mg/kg，猴 >467 mg/kg。兔急性經(jīng)皮LD50 >2000 mg/kg，對(duì)兔眼和皮膚有輕微刺激。大鼠急性吸入LC50 (4 h) 0.32 mg/l 空氣。2年飼喂試驗(yàn)無作用劑量：大鼠3.75 mg/kg天、小鼠5.0 mg/kg天。日本鵪鶉急性經(jīng)口LD50 2023 mg
包裝 25kg紙板桶。
性狀描述 無色晶體，原藥為淺棕褐色晶體，熔點(diǎn)173－174℃，蒸氣壓5.7mPa(20℃)， 密度1.44g/ml(20℃)，溶解度水35mg/L(25℃)，二氯甲烷150，丙酮8，甲醇5， 二甲苯3(g/kg，25℃)，pH6穩(wěn)定，pH9很快水解，pH3緩慢水解(DT50約9天)， 其水懸液在日光下分解。60℃以下穩(wěn)定。Composition:Tech. grade is 96% pure.Form:Colourless crystals; (tech., pale tan crystals). M.p.: 173-174 ℃ B.p.: V.p.: 5.7 mPa (20 ℃) Henry: S.g./density: 1.44 g/ml (20 ℃) Solubility: In water 35 mg/l (25 ℃). In dichloromethane 150, acetone 8, methanol 5, xylene 3 (all in g/kg, 25 ℃).Stability: Stable at pH 6, rapidly hydrolysed at pH 9 and slowly at pH 3 (DT50 c. 9 d). Aqueous suspensions are decomposed by sunlight. Stable up to 60 ℃. F.p.:
毒 理 學(xué) 性 質(zhì)
LD50/LC50 急性經(jīng)口：66mg/kg；急性經(jīng)皮：>2000mg/kg(兔)。Oral: Acute oral LD50 for rats 66 (in water), 120 (in corn oil), dogs >800, monkeys >467 mg/kg.Skin and eye Acute percutaneous LD50: for rabbits >2000 mg/kg; slightly irritating to their eyes and skin. Inhalation: (4 h) for rats 0.32 mg/l air.Birds: Acute oral LD50 for Japanese quail 2023 mg/kg. Dietary LC50 for mallard duck 5620 mg/kg diet.Fish: LC50 (96 h) for bluegill sunfish 1.21, rainbow trout 2.55 mg/l.Bees: Moderately toxic to bees exposed to direct spray. No hazard to honeybees after spray residues have dried.Daphnia: LC50 (48 h) 0.053 mg/l.Algae: Worms: Other aquatic spp.:
NOEL (2 y) for rats 3.75, mice 5.0 mg/kg daily.
NOAEL ▲
LOAEL ▲
ADI (JMPR) 0.03 mg/kg b.w. [1986].
BMD ▲
PTWI ▲
PTDI ▲
RfD ▲
MTD ▲
Acute RfD ▲
是否致癌物 ×
是否基因致癌物 ×
其他毒理學(xué)性質(zhì) 中等毒。Toxicity class EPA(formulation): II
其 他 信 息
類別 殺蟲劑
作用 Biochemistry: Cholinesterase inhibitor. Mode of action: Insecticide with predominantly stomach action, but also limited contact action. As a seed treatment, rapidly translocated systemically through the plant. Molluscicide which provokes paralysis and death. Uses: Control of all stages of major Lepidoptera and Coleoptera pests and some Hemiptera and Diptera on cotton, soya beans, maize, vines, fruit, vegetables, and many other crops at 200-1000 g/ha; seed treatment rates are 2500-10 000 g/tonne. Also used as a molluscicide for control of slugs in cereals and oilseed rape. Phytotoxicity: Compatibility: Incompatible with acidic and alkaline substances, certain heavy-metal oxides, and salts of certain fungicides such as maneb, mancozeb (except WP formulations), cuprammonium carbonate, or Bordeaux mixtures. Not miscible with vegetable oil diluents.
作用特點(diǎn) 抑制昆蟲體內(nèi)的膽堿酯酶，使昆蟲致死。但這是一種可逆性抑制，如果昆蟲 不中毒死亡，酶可以脫氨基甲�；謴�(fù)。
代謝情況 Animals: In rats, rapidly degraded to methomyl, which was rapidly converted to methomyl methylol, oxime, sulfoxide and sulfoxide oxime. These unstable intermediates were converted to acetonitrile and CO2, which were eliminated primarily by respiration and in the urine; a small fraction of acetonitrile was further degraded to acetamide, acetic acid and CO2 (K. Huhtanen & H. W. Dorough, Pestic. Biochem. Physiol., 1976, 6, 571-583). Plants: Major metabolites include thiodicarb methomyl, acetonitrile and CO2. Soil/environment: Rapidly degraded in soils of various types, under both aerobic and anaerobic conditions, by hydrolysis and photolysis. The primary degradation products are methomyl and methomyl oxime. DT50 of thiodicarb in soil is 3-8 d, depending upon the soil type.
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